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41.
Nonribosomal Peptides Produced by Minimal and Engineered Synthetases with Terminal Reductase Domains
Andreas Tietze Dr. Yan-Ni Shi Dr. Max Kronenwerth Prof. Dr. Helge B. Bode 《Chembiochem : a European journal of chemical biology》2020,21(19):2750-2754
Nonribosomal peptide synthetases (NRPSs) use terminal reductase domains for 2-electron reduction of the enzyme-bound thioester releasing the generated peptides as C-terminal aldehydes. Herein, we reveal the biosynthesis of a pyrazine that originates from an aldehyde-generating minimal NRPS termed ATRed in entomopathogenic Xenorhabdus indica. Reductase domains were also investigated in terms of NRPS engineering and, although no general applicable approach was deduced, we show that they can indeed be used for the production of similar natural and unnatural pyrazinones. 相似文献
42.
Maria Jos G. Fernandes Renato B. Pereira David M. Pereira A. Gil Fortes Elisabete M. S. Castanheira M. Sameiro T. Gonalves 《International journal of molecular sciences》2020,21(23)
Eugenol, the generic name of 4-allyl-2-methoxyphenol, is the major component of clove essential oil, and has demonstrated relevant biological potential with well-known antimicrobial and antioxidant actions. New O-alkylated eugenol derivatives, bearing a propyl chain with terminals like hydrogen, hydroxyl, ester, chlorine, and carboxylic acid, were synthesized in the present work. These compounds were later subjected to epoxidation conditions to give the corresponding oxiranes. All derivatives were evaluated against their effect upon the viability of insect cell line Sf9 (Spodoptera frugiperda), demonstrating that structural changes elicit marked effects in terms of potency. In addition, the most promising molecules were evaluated for their impact in cell morphology, caspase-like activity, and potential toxicity towards human cells. Some molecules stood out in terms of toxicity towards insect cells, with morphological assessment of treated cells showing chromatin condensation and fragmentation, which are compatible with the occurrence of programmed cell death, later confirmed by evaluation of caspase-like activity. These findings point out the potential use of eugenol derivatives as semisynthetic insecticides from plant natural products. 相似文献
43.
Asli Agirbas 《建筑学研究前沿(英文版)》2020,9(4):940-950
This study aims to test two hypotheses: teaching building information modeling (BIM) in relation to construction science provides students with a remarkable understanding of the nature of construction science (Hypothesis 1), and if the student has positive attitude toward the use of the BIM program, then efficiency by which construction science is taught by its means is improved (Hypothesis 2). Results and process of a case study with a novel teaching methodology were discussed in terms of the benefits of the students. A questionnaire study was conducted on the student group with which the case study was performed to test each student's attitude. Results were evaluated statistically. When BIM is integrated with the teaching of basic construction courses within architecture degree programs, the students understood the building system principles simply and effectively. As a result of the statistical analysis, the students find the applied method effective. Moreover, their attitude toward BIM affects the process. 相似文献
44.
《International Journal of Hydrogen Energy》2020,45(35):18021-18031
Laser ignition (LI) is emerging as a strong technology to control the oxides of nitrogen (NOx) emissions from spark ignition (SI) engines without the need for any significant exhaust gas after-treatment and is an appropriate technology for meeting future emission norms in the automotive sector. In this study, particulate characteristics of LI engine fuelled with different compressed natural gas (CNG) and hydrogen mixtures [100% CNG, 10HCNG (10% v/v hydrogen with 90% v/v CNG), 30HCNG (30% v/v hydrogen with 70% v/v CNG), 50HCNG (50% v/v hydrogen with 50% v/v CNG) and 100% hydrogen] were investigated. Experiments were performed in a suitably modified single cylinder engine, which operated in LI mode at constant engine speed (1500 rpm) at five different engine loads (5, 10, 15, 20 and 25 Nm). Particulate characteristics were determined using an engine exhaust particle sizer (EEPS). Results showed that particle number concentration increased with increasing engine load. Number-size, surface area-size and mass-size distributions of particulates reflected that addition of hydrogen in the CNG improved particulate emission characteristics especially in nucleation mode particle (NMP) size range (10 nm < Dp < 50 nm). Among the test fuels, hydrogen-fuelled engine emitted the lowest number of particles. It was observed that the difference between particulate characteristics emitted by different test fuels reduced at higher engine loads. Significant contribution of lubricating oil in particulate emissions from both hydrogen as well as HCNG fuelled LI engine was an important finding of this study. Dominant contribution of larger particles (Dp > 50 nm) in total particle mass (TPM) was an important observation of this study. The qualitative correlation between total particle number (TPN) and TPM indicated that suitable fuel composition at different engine loads yielded cleaner exhaust from the LI engine. Overall, this study demonstrated that addition of hydrogen in CNG is advantageous from particulate reduction point of view, however, optimum fuel composition should be adjusted according to engine operating condition in order to reduce particulate emissions. 相似文献
45.
采用季戊四醇锌与月桂酸锌并用作为硫化活性剂,考察其对天然橡胶硫化特性及物理机械性能的影响。结果表明,季戊四醇锌具有较高的硫化活性,可使胶料的硫化速率加快,硫化活化能下降,硫化活性高于月桂酸锌,但抗硫化返原性能较差,胶料的物理机械性能较低,耐磨性较差。将季戊四醇锌与月桂酸锌并用可产生硫化协同效应,明显提高胶料的表观交联密度,改善抗硫化返原性能,同时还能降低门尼黏度、提高填料分散性并降低生热和滚动阻力。加入6.70份季戊四醇锌并用5.56份月桂酸锌的天然橡胶硫化胶,其综合性能优于添加5.00份氧化锌的硫化胶,并且含锌质量分数减少48%。 相似文献
46.
In this work, we study the capacitive properties of gel-type natural abundant polymers without any dopants, mainly commercial gelatin and agar in deionized water. Here, we propose a facile fabrication of flexible, transparent, and planar electrolytic capacitors using these gel-type and indium tin oxide thin films as electrodes deposited on poly(ethylene terephthalate) substrates. Through cyclic voltammetry and galvanostatic charge–discharge techniques, we found that the devices show a specific capacitance in the order of the millifarads per gram, a specific power of ~10 mW cm−2, which is sufficient to active low-power devices, and a life cycle with nearly 100% efficiency after 1,000 cycles. We found that we do not need to add dopants that improve the ionic conductivity of the natural polyelectrolytes to obtain capacitances within the millifarads per gram. The flexibility of the capacitors was demonstrated by bending them, after which they exhibited the same electrochemical performance as the unbent devices. The optical transparency of the capacitors was measured by UV–V is spectroscopy showing a high transmittance in the visible region. 相似文献
47.
Oxoisoaporphine Alkaloids: Prospective Anti‐Alzheimer's Disease,Anticancer, and Antidepressant Agents 下载免费PDF全文
Oxoisoaporphine alkaloids are a family of oxoisoquinoline‐derived alkaloids that were first isolated from the rhizome of Menispermum dauricum DC. (Menispermaceae). It has been demonstrated that oxoisoaporphine alkaloids possess various biological properties, such as cholinesterase and β‐amyloid inhibition, acting as a topoisomerase intercalator, monoamine oxidase A inhibition, and are expected to become anti‐Alzheimer's disease, anticancer, and antidepressant drugs. This review provides an overview of natural sources, synthetic routes, bioactivities, structure–function relationship, and modification investigations into oxoisoaporphine alkaloids, with the aim of providing references to the structure–activity relationships for the design and development of oxoisoaporphine derivatives with higher efficacy and therapeutic potential. 相似文献
48.
Herein, electrically conductive natural and synthetic yarns through electrophoretic deposition (EPD) technique were fabricated. A parametric study on the conductivity enhancement of the yarns is carried out by Taguchi method. Using this method, the desirable conditions are determined by studying the effects of important parameters on the electrical conductivity of the yarns in the EPD coating process. Based on the L18 design of experiments table, the preferred combination of factors to obtain the highest electrical conductivity of the yarns is found by Taguchi analysis. In addition, the Pareto ANOVA analysis is conducted to identify the major contributing factors on the electrical conductivity of the yarns. Characterisation techniques, such as scanning electron microscopy (SEM), Fourier transformed infrared spectroscopy (FTIR) in attenuated total reflectance (ATR) mode, and thermogravimetric analysis (TGA) are utilised for better understanding the microstructure and physical properties. When powered by only 3 V, the maximum temperature of a Joule heated conductive sample based on natural fibre yarns reached 102°C in less than 25 s. 相似文献
49.
Dr. Camila M. Crnkovic Dr. Jana Braesel Dr. Aleksej Krunic Prof. Dr. Alessandra S. Eustáquio Prof. Dr. Jimmy Orjala 《Chembiochem : a European journal of chemical biology》2020,21(6):845-852
Cyanobactins are a large family of cyanobacterial ribosomally synthesized and post-translationally modified peptides (RiPPs) often associated with biological activities, such as cytotoxicity, antiviral, and antimalarial activities. They are traditionally described as cyclic molecules containing heterocyclized amino acids. However, this definition has been recently challenged by the discovery of short, linear cyanobactins containing three to five amino acids as well as cyanobactins containing no heterocyclized residues. Herein we report the discovery of scytodecamide ( 1 ) from the freshwater cyanobacterium Scytonema sp. UIC 10036. Structural elucidation based on mass spectrometry, 1D and 2D NMR spectroscopy, and Marfey's method revealed 1 to be a linear decapeptide with an N-terminal N-methylation and a C-terminal amidation. The genome of Scytonema sp. UIC 10036 was sequenced, and bioinformatic analysis revealed a cyanobactin-like biosynthetic gene cluster consistent with the structure of 1 . The discovery of 1 as a novel linear peptide containing an N-terminal N-methylation and a C-terminal amidation expands the chemical and genetic diversity of the cyanobactin family of compounds. 相似文献
50.
Hans Jagusch Tim U. H. Baumeister Prof. Dr. Georg Pohnert 《Chembiochem : a European journal of chemical biology》2020,21(17):2419-2424
Oxylipins constitute a family of oxidized fatty acids, that are well known as tissue hormones in mammals. They contribute to inflammation and its resolution. The major classes of these lipid mediators are inflammatory prostaglandins (PGs) and leukotrienes (LTs) as well as pro-resolving resolvins (Rvs). Understanding their biosynthetic pathways and modes of action is important for anti-inflammatory interventions. Besides mammals, marine algae also biosynthesize mammalian-like oxylipins and thus offer new opportunities for oxylipin research. They provide prolific sources for these compounds and offer unique opportunities to study alternative biosynthetic pathways to the well-known lipid mediators. Herein, we discuss recent findings on the biosynthesis of oxylipins in mammals and algae including an alternative pathway to prostaglandin E2, a novel pathway to a precursor of leukotriene B4, and the production of resolvins in algae. We evaluate the pharmacological potential of the algal metabolites with implications in health and disease. 相似文献